Legend is the only FDA approved I.V. and intra-articular therapy to treat equine non-infectious synovitis associated with osteoarthritis. Legend is pure hyaluronate sodium, the same glycosaminoglycan present in normal joint fluid. Legend is produced by a patented biofermentation process, resulting in such purity that it can be given intravenously for immediate bioavailability.

Key Benefits:

• Helps treat joint dysfunction in horses
• Targets inflammation of the lining of the joint capsule
• Injectable form of hyaluronate reaches the problem area quickly

How It Works

The actual mechanism of action for hyaluronate sodium in the healing of degenerative joint disease is not completely understood. One major function appears to be the regulation of normal cellular constituents. This effect decreases the impact of exudation, enzyme release and subsequent degradation of joint integrity. Additionally, hyaluronate sodium exerts an anti-inflammatory action by inhibiting the movement of granulocytes and macrophages. Hyaluronate molecules are long chains which form a filter network interspersed with normal cellular fluids. It is widely accepted that injection directly into the joint pouch enhances the healing of inflamed synovium by restoring lubrication of the joint fluid. This further supplements the visco-elastic properties of normal joint fluid.

Indications

LEGEND (hyaluronate sodium) Injectable Solution and LEGEND Multi Dose (hyaluronate sodium) Injectable Solution is indicated in the treatment of joint dysfunction of the carpus or fetlock in horses due to non-infectious synovitis associated with equine osteoarthritis.

LEGEND Multi Dose (20 mL) and LEGEND 4 mL (40 mg) injected intravenously only. LEGEND 2 mL (20 mg) injected intravenously or intra-articularly in the carpus or fetlock. Treatment may be repeated at weekly intervals for a total of three treatments.

LEGEND Injectable Solution 2 mL: Strict aseptic technique should be observed when administering by intra-articular injection. As with any intra-articular procedure, proper injection site disinfection and animal restraint are important. Excess joint fluid should be aseptically removed prior to injection. Care should be taken to avoid scratching the cartilage surface with the tip of the injection needle. Diffuse swelling lasting 24 to 48 hours may result from movement of the needle while in the joint space.

For intravenous administration, use aseptic technique and inject slowly into the jugular vein.

Horses should be given stall rest after treatment before gradually resuming normal activity.

LEGEND Injectable Solution 2 mL and 4 mL only: Discard any unused portion of the drug and the empty vial after opening