ilium senabolic
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ilium senabolic The androgenic anabolic steroid nandrolone decanoate prevents osteopenia and inhibits bone turnover in ovariectomized cynomolgus monkeys
ilium senabolic The androgenic anabolic steroid standalone decapitate prevents osteopaths and inhibits bone turnover in overspecialized cynosures monkeys We examined the effects of standalone decanoate (25 mg im every 3 weeks) on bone mass, serum biomarkers, and bone
historiographer endpoints in 52 female macaques randomized into four treatment groupsilium : (1) sham-overspecialized (sham); o+ placebo for 2 years (ovx); (3) ovx +decanoate for 2 years (Nan); and (4) ovx + n beginning 1 year after ovx (dNan). Serum alkaline phosphate (ALP), o and tartrate-resistant acid p (TRAP) were assayed every 3 months, and X-ray densitometry of the lumbar spine was done every 6 months. e-labeled iliac biopsies collected at baseline and 1 year, and lumbar vertebrae a femur collected at 2 years,
were evaluated . Body weight increased over 50% with administration ofe. After 2 years, ovx animals had lower spinal BM BMD than all other groups. Ovx animals also had higher bone turnover rates than all other groups, as indicated by higher levels of the serum and urine biomarkers, and by at least twofold higher label-based bone formation rates in the femur diaphysis and in both cancellous and cortical bone of the ilium and
vertebral bodies. N-treated animals had similar serum estradiol levels as the sham animals, presumably due to conversion of endogenous or exogenous androgens. The effects of nandrolone on bone in this experiment are consistent with estradiol action and may be attributable to the increased serum estradiol. Despite >50% higher body weight, e-treated,animals did not have higher bone mass than sham animals.
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