Pentosan Injection 250mg/ml, 50ml – Advanced Osteoarthritis Treatment for Horses

Introduction: A Breakthrough in Equine Joint Care

Joint disease and osteoarthritis are among the most common causes of pain, stiffness, and reduced performance in horses. Traditional treatments such as NSAIDs or corticosteroids may relieve symptoms but often suppress cartilage healing and fail to address the root cause of joint degeneration. Pentosan Injection 250mg/ml, 50ml offers a sophisticated, science-backed solution that not only reduces inflammation but actively stimulates cartilage synthesis, repair, and protection—helping horses regain mobility, comfort, and long-term joint health.

What Is Pentosan Injection?

Pentosan Injection is a concentrated anti-inflammatory and cartilage stimulant formulated with sodium pentosan polysulfate (PPS), a plant-derived compound from beechwood xylan. PPS belongs to the sulfated heparinoid family but has been refined to reduce anticoagulant effects while enhancing anti-inflammatory, fibrinolytic, and tissue-protective properties.

• Composition: Sodium pentosan polysulfate 250mg/ml.
• Presentation: 50ml sterile single-dose glass vial.
• Administration Routes: Intramuscular (IM), intravenous (IV), or intra-articular (IA).

Key Features & Benefits

1. Stimulates Cartilage Repair

• Activates chondrocyte metabolism, increasing proteoglycan and cartilage matrix production.
• Stimulates synovial fibroblasts to produce high molecular weight hyaluronic acid.
• Improves joint fluid volume and viscosity for better lubrication and stabilization.

2. Potent Anti-Inflammatory Action

• Inhibits mediators of the arachidonic acid cascade.
• Blocks enzymes such as histamine, hyaluronidase, cathepsin B, and elastase.
• Preserves cartilage and prevents release of inflammatory mediators.
• Provides lasting pain relief and inflammation control.

3. Fibrinolytic & Lipolytic Effects

• Stimulates plasminogen activator release, dissolving fibrin deposits in synovial tissues.
• Mobilizes lipids and cholesterol in joint blood vessels, improving circulation.
• Enhances cartilage healing and repair by increasing perfusion to the joint.

4. Long-Term Joint Management

• Promotes healing rather than masking pain.
• Safe alternative to NSAIDs and corticosteroids, which can damage cartilage with prolonged use.
• Provides improvement lasting up to six months after a treatment course.

Indications

Pentosan Injection is recommended for horses suffering from:

• Non-infectious inflammatory joint disease.
• Traumatic arthritis.
• Osteoarthritis.
• Degenerative cartilaginous joint disease.
• Osteochondrosis dessicans.

Dosage & Administration

• Intravenous (IV): 3mg/kg bodyweight (1.5g for a 500kg horse) at 5–7 day intervals for four injections.
• Intra-Articular (IA): 1ml sterile injection directly into the joint.
• Treatment Course: Four injections provide sustained improvement for up to six months.
• Additional Use: Safe to administer further injections if soreness recurs after activity.
• Synergy: Works particularly well with Cosequin Equine (Glucosamine + Chondroitin sulfate) to provide raw materials for joint repair.

Storage Instructions

• No refrigeration required.
• Store below 25°C and protect from light.

Contraindications

Do not use Pentosan Injection in horses with:

• Clotting defects or traumatic hemorrhage.
• Active infection.
• Renal or hepatic failure.
• Within 48 hours of surgery.

Why Choose Pentosan Injection?

• Advanced Joint Therapy: Stimulates cartilage repair and joint fluid production.
• Safe & Effective: Non-steroidal, does not suppress healing.
• Long-Term Relief: Improvement lasting months after treatment.

• Trusted in Equine Medicine: Widely used for managing osteoarthritis and joint degeneration.

Restoring Mobility & Comfort in Horses

Pentosan Injection 250mg/ml, 50ml is more than an anti-inflammatory—it’s a comprehensive joint therapy that actively repairs and protects cartilage while relieving pain. By addressing the root causes of osteoarthritis, Pentosan helps horses regain mobility, comfort, and performance for the long term.

Order Pentosan Injection today and give your equine partner the advanced joint care they deserve.