Dexamedium 50ml  is a potent synthetic glucocorticoid with low mineralocorticoid activity. It has 10 to 20 times the anti-inflammatory activity of prednisolone equivalent molar dose.

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Pharmacodynamic properties:

Dexamedium 50ml  is a potent synthetic glucocorticoid with low mineralocorticoid activity. It has 10 to 20 times the anti-inflammatory activity of prednisolone equivalent molar dose.
Corticosteroids can decrease the immune response. Indeed, they inhibit capillary dilatation, leukocyte migration and phagocytosis.
Glucocorticoids have an effect on metabolism by increasing gluconeogenesis.
Pharmacokinetic properties:
After IM administration of the product: dexamethasone tebutate is absorbed relatively slowly, prolonging the duration of action of dexamethasone for 3 to 4 days. The T max in cattle and dogs respectively 28 and 22 h after administration. T 1/2 (half-life time) varies between 61 hours in cattle and 50 hours in dogs. Bioavailability of about 100%.

Special precautions for use:
Shake the bottle well before use.
The administration of corticosteroids at the end of gestation can lead to premature delivery or abortion in ruminants.
Except in the indications for acetonemia, the function of corticosteroids is to provide improvement rather than cure. It is therefore advisable to diagnose and treat the underlying disease.
When used to treat shock, intravenous fluids must be administered to maintain circulation. An acid-base balance must be carried out.
Precautions for pregnancy and lactation:
Studies in laboratory animals have shown embryotoxic effects.
The use of corticosteroids in pregnant animals is not recommended.
Interactions:
Since corticosteroids may reduce the immune response to vaccination, dexamethasone should not be administered concurrently with vaccines.
Concomitant administration of NSAIDs may increase the risk of ulceration of the gastrointestinal tract.
Special precautions for users:
In case of accidental self-injection, seek medical advice immediately and show the package leaflet.
People with known hypersensitivity to the active substance or to any of the excipients should avoid contact with the veterinary medicinal product.
Pregnant women should not handle this medicine.